Research
Requirements
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Our most urgent priority right now. For the first time, we are counting every case of pregnancy AKI across the world simultaneously describing the true global burden and making it impossible to ignore.
The Global PrAKI Snapshot
What we already know: The Global Survey
79 countries. 1,173 responses. The picture is stark.
- In low-income settings, 67% of clinicians rely on clinical judgement alone with no standardised protocol to guide them
- Creatinine testing, the basic tool for diagnosing AKI, is unavailable in 42% of low-income facilities
- Nephrology follow-up is available to 76% of patients in high-income settings. In low-income settings: 20%
- Midwives and nurses, the clinicians most likely to be in the room, had low PrAKI knowledge across every setting
- Across all income groups, the top ask was the same: better guidelines, hands-on training and decision-support tools
Our Research Priorities
At our inaugural meeting in Nairobi in July 2025, 41 participants from 14 countries mapped the most urgent research needs in PrAKI against WHO's six health system building blocks. Six priority areas emerged:
- Earlier recognition — pregnancy-specific renal physiology, point-of-care creatinine testing and risk-prediction tools.
- Safer management — clearer blood pressure targets and fluid strategies in hypertensive disorders and obstetric emergencies.
- Robust information systems — quantifying burden, disentangling causality with adverse pregnancy outcomes, and following mothers and infants longitudinally.
- Workforce capability — curriculum integration, standardised protocols and competency-based training.
- Service integration — embedding kidney testing within routine maternity pathways and reducing diagnostic delay through community-level awareness.
- Economic case — building the evidence for extended postnatal follow-up and long-term kidney health investment.
A modified Delphi process is underway to further refine these priorities and guide Consortium research activity.
What We Are Working On
• Community approaches to improve antenatal and postnatal care
• Fluid balance strategies in maternity settings
• CKD prevention following PrAKI
• Novel intrapartum care approaches to reduce PrAKI events and impact
• Point-of-care ultrasound (PoCUS) in PrAKI management
Core Outcome Set
A working group within the Consortium is developing a Core Outcome Set to guide researchers and clinical coders working in PrAKI ensuring that future studies measure what matters. A modified Delphi questionnaire will be circulated soon. This work is registered with COMET
Partners in Innovation
Phase two of the Global Snapshot will use point-of-care devices in partnership with Eaglenos and Microlife bringing diagnostics to settings where laboratory testing is unavailable.
Collaborate With Us
We have the clinical expertise, the global network and the will. What we need is funding to match the scale of the problem. If you are a researcher, institution or funder who wants to work with us, we would love to hear from you. We are particularly keen to hear from groups working in: maternal health, global nephrology, implementation science, digital health and health economics.
The evidence to end PrAKI doesn't exist yet. We are building it. Please help.
Too many mothers are dying from a condition that is preventable, under-measured and under-researched. The Global PrAKI Consortium exists to close that gap with rigorous, global, equity-focused research that turns evidence into action.